Aging and drug discovery
Multiple interventions in the aging process have been discovered to extend the healthspan of model organisms. Both industry and academia are therefore exploring possible transformative molecules that target aging and age‐associated diseases. In this overview, we summarize the presented talks and discussion points of the 5th Annual Aging and Drug Discovery Forum 2018 in Basel, Switzerland. Here academia and industry came together, to discuss the latest progress and issues in aging research. The meeting covered talks about the mechanistic cause of aging, how longevity signatures may be highly conserved, emerging biomarkers of aging, possible interventions in the aging process and the use of artificial intelligence for aging research and drug discovery. Importantly, a consensus is emerging both in industry and academia, that molecules able to intervene in the aging process may contain the potential to transform both societies and healthcare ; DB is supported by the German Research Foundation (Forschungsstipendium; BA 6276/1-1). CYE is supported by Swiss National Science Foundation [163898]. VNG is supported by grants from National Institutes of Health, and by the Russian Federation grant 14.W03.31.0012. DWL presented the results of research supported in part by research grants and funds from the National Institutes of Health, the Wisconsin Partnership Program, the Progeria Research Foundation, the American Federation for Aging Research, and the University of Wisconsin-Madison School of Medicine and Public Health and Department of Medicine, as well as the facilities and resources of the William S. Middleton Memorial Veterans Hospital. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. This work does not represent the views of the Department of Veterans Affairs or the United States Government. MSL is supported by an LUMC research fellowship and a VIDI grant from the Netherlands scientific organization (NWO- ALW-016.161.320). A.M.-M. is supported by grants from the Instituto de Salud Carlos III co-funded by Instituto de Salud Carlos III and FEdeR (CP14/00105 and PI15/00134). SM was supported by the FWO-OP/Odysseus program (42/FA010100/32/6484). SJO's current work is funded by The Glenn Award from the Glenn Foundation for Medical Research. MR is supported by the Swiss National Science Foundation and the European Union Horizon 2020 program. MSK is supported by grants from the Danish Cancer Society (#R167-A11015_001), the Independent Research Fund Denmark (#7016- 00230B) and the Novo Nordisk Foundation (NNF17OC0027812). ; Peer reviewed